Triple negative breast cancer: microRNA expression profile and novel discriminators according to BRCA1 status
نویسندگان
چکیده
منابع مشابه
Comparison of BRCA1 Expression between Triple-Negative and Luminal Breast Tumors
Background: Previous studies have suggested that BRCA1 dysregulation has been shown to have a role in triple-negative phenotypic manifestation. However, differences of BRCA1 expression, as a tumor suppressor gene, have rarely been investigated between luminal and triple-negative breast tumors. Therefore, the present study attempted to compare the BRCA1 expression in triple-negative with lu...
متن کاملMicroRNA Therapeutics in Triple Negative Breast Cancer
Breast cancer is a complex disease and one of the main causes of cancer-related mortality in women worldwide. In case of approximately 15% of all breast cancers, three markers i.e. estrogen receptors (ER), progesterone receptors (PR) and human epidermal growth factor receptors-2 (HER2) are not express, and is commonly termed as triple-negative breast cancer (TNBC). Particularly, TNBC is associa...
متن کاملAssociation of HDAC8 Expression with Pathological Findings in Triple Negative and Non-Triple Negative Breast Cancer: Implications for Diagnosis
Background: Previous data have shown the tumorigenicity roles of HDAC8 in breast cancer. More recently, the oncogenic effects of this molecule have been revealed in TNBC. The present study aimed to determine the diagnostic value of HDAC8 for the differentiation of TNBC from nTNBC tumors. Methods: A total of 50 cancerous and normal adjacent tumor specimens were obtained, and the clinical and pat...
متن کاملBRCA1 mutation in the Triple- Negative Breast Cancer Group
Material and methods 332 unselected patients with invasive breast cancer diagnosed between 20062011 were identified from Pauls Stradins Clinical University Hospital, Riga East University hospital databases and clinical data from medical records were retrospectively analyzed. All patients were tested for the two common founder mutations in BRCA1 (4153delA and 5382insC) in Latvia using a multiple...
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Emerging evidence suggests that BRCA1 pathway contributes to the behavior of sporadic triple negative breast cancer (TNBC), but little is known about the mechanisms underlying this association. Considering the central role that microRNAs (miRNAs) play in gene expression regulation, the aim of this study was to identify miRNAs specifically deregulated in TNBC and investigate their involvement in...
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ژورنال
عنوان ژورنال: Journal of Cellular Physiology
سال: 2019
ISSN: 0021-9541,1097-4652
DOI: 10.1002/jcp.29398